A novel enhanced quantum particle swarm optimization algorithm for IIoT deployments is proposed. It provides enhanced connectivity, reduced energy consumption, and optimized delay. We consider heterogeneous scenarios of network topologies for optimal path configuration by exploring and exploiting the hunts. It uses multiple inputs from heterogeneous IIoT into quantum and bio-inspired optimization techniques. The differential evolution operator and crossover operations are used for information interchange among the nodes to avoid trapping into local minima. The different topology scenarios are simulated to study the impact of p-degrees of connectivity concerning objective functions' evaluation and compared with existing techniques. The results demonstrate that our algorithm consumes a minimum of 30.3% lesser energy. Furthermore, it offers improved searching precision and convergence swiftness in the possible search space for p-disjoint paths and reduces the delay by a minimum of 26.7%. Our algorithm also improves the throughput by a minimum of 29.87% since the quantum swarm inclines to generate additional diverse paths from multiple source nodes to the gateway. © 2013 IEEE.