Traditional heat transfer liquids show very fewer thermal characteristics. Consequently, there is truly expanding request to foster liquids having excessive thermal characteristics. Thermo-liquid characteristics assume a crucial part in the refinement of such high heat transfer proficient gadgets. A nano liquid is an involvement of nano estimated particles be made of oxides, metals in a base liquid of oil, water, distilled water, or ethylene glycol of size up to 100 nm. As of late enormous quantities of analyses have been are done to assess the impact of nano liquid in rate of heat transfer improvement in different heat exchangers. The amplification of heat transfer utilizing nano liquid for the most part relies upon sort of nano molecules, state of nano molecules, kind of foundation liquid and concentration of nano molecules in the foundation liquid. In the current study, CFD assessment has been completed to decide the impact of different concentration of CuO nano molecules blended in distilled water on heat transfer attributes of shell and tube heat exchanger for counterflow positioning. CuO nano liquid of volume concentration 0.01% and 0.02% are prepared theoretically. The end inferred for the research is that coefficient of overall heat transfer and rate of overall heat transfer increments with expansion in CuO nano molecules volume concentration contrasted with distilled water. © 2022