The aim of the current study was the development of Esomeprazole buccal adhesive tablets using direct compression. Buccoadhesive tablets of Esomeprazole which were designed to prolong the buccal residence time after oral administration. Buccal adhesive formulations were developed using with various combinations of mucoadhesive polymers namely, Carbopol 934 P, HPMC K4M, sodium alginate. The prepared Esomeprazole tablets were evaluated for weight variation, thickness, hardness, surface PH, content uniformity and swelling index. In-vitro drug Permeation Studies by egg membrane, ex-vivo drug Permeation Studies by goat membrane. The effect of formulation composition on the release pattern was also investigated. Most formulations showed Esomeprazole controlled release profiles depended on the grade and polymer ratio. Tablets containing Carbopol 934 P and sodium alginate in the ratio of 1:1(B3) showed the maximum drug release of 94.16% in 8 hours. The swelling index was proportional to sodium alginate content and inversely proportional to Carbopol 934 P content. Formulation B3 showed maximum swelling index after 6 hours. The surface pH of all tablets was found close to neutral PH. The release mechanisms were found to fit Peppas' kinetic model. {\textcopyright} RJPT All right reserved.