The shift over of the automobile sector from the ICE to the electric drives is imminent due to arising global issues of pollution and ever rising pressure on the demand of the natural resources due to lower efficiency of the ICE drives. This has led to uprising of the Lithium-ion batteries, with addition of the burden of living to expectation of clean energy and higher efficiencies. Alongside, with limitation in the availability of the lithium-ion batteries they carry a hefty price tag with them, hence causing huddles in the research. Lack of research leads to failure of batteries and may cause life threatening situations when operating in the vehicle. In order to insight the working of the lithium-ion batteries under different driving and environmental conditions an analytical model is developed for the coupled electro-chemical and thermal phenomenon. This allows anticipating the behaviour of the battery under different conditions that influence its performance. The 18650 cylindrical batteries with three different chemistries i.e. Lithium Nickel Cobalt Aluminium Oxide (NCA), Lithium Nickel Manganese Cobalt Oxide (NMC) and Lithium Iron Phosphate (LFP) are used to validate the analytical methodology. The experimental measurements of these batteries are carried out initially to predict the surface temperature of the batteries under defined load cycles. Further the surface temperatures of the batteries are analytically determined with the aid of developed model in this research. The analytical analysis includes calculating the SOC, followed by evaluating the internal resistance of the battery at that particular instance and then determining the temperature by solving the energy balance equation using suitable numerical technique. The virtual simulations of the batteries are also carried out using the commercially available Multiphysics software. The developed analytical methodology is validated using the experimental and virtual approach. The developed methodology will assist in predicting the performance of the battery in the battery pack and also to ensure the application of efficient thermal management system. © 2021 SAE International. All rights reserved.