Difluoromethane (HFC32) is the perfect replacement of R410A due to its lower Global warming potential (GWP as 675) that is much less than R410A (2088) and Zero Ozone Depletion Potential. R32 can achieve higher heat transfer coefficients with less quantity of refrigerant charge amount when compared to R410A. Tube-Fin heat exchangers (TFHE) are widely used in the refrigeration, air conditioning industries and in many other applications to exchange or transfer the heat from refrigerant or working fluid to the sink. The aim of this paper is to calculate the Heat transfer coefficient, pressure drop and heat load of refrigerant in Air-cooled Tube-Fin heat exchanger as a condenser in one TR residential air conditioner application and their comparison using R32 and R410A. To study the refrigerant behaviour in liquid, two phase and vapour forms inside the condenser using two refrigerants. Materials used were Aluminium for fins and copper for tubes to achieve greater heat transfer coefficient. Optimizing the design of TFHE that is selecting the micro finned tubes to generate turbulence in refrigerant flow, which results in enhancement of heat transfer coefficient. The micro finned copper tubes with smaller inner diameter can save the material cost. Coil Designer a simulation software used for the design and analysis of TFHE.