Two simple, economical, precise and accurate methods for simultaneous determination of Drotaverine (DRT) and Nimesulide (NIM) in combined dosage form have been developed. The first method is Ratio Derivative spectroscopy method (Method A) in which ratio derivative amplitudes were measured at selected wavelengths. Second method is Dual wavelength Spectrophotometry (Method B). The amplitudes at 344.8 nm and 243.5 nm in the Ratio derivative spectra were selected to determine DRT and NIM, respectively and wavelengths 254.008, 274.68 nm and 221.09, 232.067 nm were selected to determine DRT and NIM, respectively by dual wavelength method in methanol. Beer's law is obeyed in the concentration ranges of 8-24 $\mu$g mL -1 and 20-60 $\mu$g mL -1 for DRT and NIM, respectively in methanol for both the methods. The % assay for commercial formulation was found to be in the range 99.91-100.91% for DRT and 99.84 - 101.07% for NIM by the proposed methods. Recovery was found in the range 99.18-100.10 for DRT and 99.52 - 101.09% for NIM by ratio derivative spectroscopic method and 99.82 - 101.12% for DRT and 99.73-101.09% for NIM by dual wavelength method for both the Formulations. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and of the proposed methods which were carried out by following ICH guidelines.