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Determination of valdecoxib from its bulk drug and pharmaceutical preparations by HPTLC
D. Baviskar T., , N. Girase O., A. Deshpande Y., D. Jain K.
Published in Indian Drug Manufacturers' Association
2007
Volume: 44
   
Issue: 10
Pages: 734 - 737
Abstract
The fast, economical, precise and highly accurate HPTLC method was developed for the determination of Valdecoxib from its bulk drug and pharmaceutical preparation. Specificity and robustness of the method was studied. Densitogram was used for representing separation of degradation product from Valdecoxib. In this method chromatography was performed on pre-coated silica gel 60 F 254 HPTLC plates (Merck # 5548). Mobile phase used was toluene-ethyl acetate, 5.0+5.0(v/v). Plates were evaluated by densitometry at $\lambda$ = 262 nm with a Camag Scanner II, in conjunction with CATS software for quantitation. The developed method can be used for the quality control and assay of the drug it requires approximately 45min for analysis.
About the journal
JournalIndian Drugs
PublisherIndian Drug Manufacturers' Association
ISSN0019462X
Open AccessNo