Content may be subject to copyright.This is a post-peer-review, pre-copyedit version of an article published in AAPS PharmSciTech. The final authenticated v... ...This is a post-peer-review, pre-copyedit version of an article published in AAPS PharmSciTech. The final authenticated version is available online at: https://doi.org/10.1208/s12249-008-9077-1. The following terms of use apply: https://www.springer.com/gp/open-access/publication-policies/aam-terms-of-use.