A simple, selective, rapid, and precise RP-HPLC-PDA method has been developed for the simultaneous estimation of Lornoxicam (LOR) and Thiocolchicoside (THIO) in pharmaceutical dosage form by reverse phase liquid chroma-tography using Waters Symmetry C18 (250 mm × 4.6 mm, 5.0 μ) column. The mobile phase consisting of metha-nol: THF: acetate buffer (60: 10: 30 v/v); pH adjusted to 5.5 with glacial acetic acid at a flow rate of 0.75 mL min-1 and column was maintained at 50 °C with detection at 382 nm. The retention time of Thiocolchicoside and Lornox-icam was 3.36 and 4.08 minutes, respectively. The method was validated according to the ICH guidelines with re-spect to specificity, linearity, accuracy, precision and robustness, limit of detection and limit of quantification. Li-nearity of Lornoxicam and Thiocolchicoside were in the range of 0.2 to 80 μg mL-1 and 0.1 to 40 μg mL-1, respec-tively and its percentage recovery were found to be 100.37 % and 100.51 %, respectively. The proposed method is suitable for simultaneous determination of Lornoxicam and Thiocolchicoside in pharmaceutical dosage form. Me-thod was successfully applied for dissolution study of tablet formulation. ©JK Welfare & Pharmascope Foundation.