Repaglinide is a widely used meglitinide class drug to treat diabetes. The current study describes degradation as per ICH guidelines (hydrolysis, photolysis, dry heat and oxidation) and optimized assay method. A simple stability indicating method has been developed for Repaglinide in bulk drug. The peak purity of the drug was observed. For HPTLC study Aluminium plates precoated with Silica Gel 60 F254 was the stationary phase and mobile phase consisted of methanol: toluene (2:8) and quantitation was done at the wavelength 242nm. The method was found to be simple, specific, precise and stability indicating. {\textcopyright} RJPT All right reserved.