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Development and validation of UV spectrophotometric method for fluindione
Thimmaraju Kumar Manish, Hemanth Kyatham, Swarnalatha P., Vinayakumar J., Kasagoni Sagar,
Published in
2015
Volume: 7
   
Issue: 2
Pages: 237 - 242
Abstract
A simple, accurate, precise, specific and highly sensitive spectrophotometric method developed for the determination of Fluindione in bulk drug.The optimum conditions for the analysis of the drug were established. The $\lambda$ max of the Fluindione was found to be 230nm in 10% methanol in 0.1N HCL. The method shows high sensitivity with linearity 1 to 5$\mu$g/ml. The regression of the curve was Y = 0.097x + 0.1277.The apparent molar absorptivity was found to be 4.79 × 104 mol-1 cm-1 in 10 % Methanol. The lower limit of detection and the limit of quantitation was found to be 0.09302$\mu$g/ml and 0.28186$\mu$g/ml respectively. All the calibration curves shows a linear relationship between the absorbance and concentration and correlation coefficient was 0.999.The proposed method will be suitable for the analysis of Fluindione in bulk form.
About the journal
JournalDer Pharmacia Lettre
ISSN09755071
Open AccessNo