The present study investigated the protective effect of the methanolic extract of fruit of Emblica officinalis (MEO) against indomethacin induced enterocolitis in male Wistar rats. Enterocolitis was induced by subcutaneous administration of indomethacin solution (7.5 mg kg-1, 2 days) for 2 days. The study comprised of 5 groups (n = 6), normal saline-treated, enterocolitis induced, MEO treated groups (100 and 200 mg kg-1, p.o.) and sulfasalazine treated (500 mg kg-1, p.o.) group. On the fourth day animals were sacrificed by cervical dislocation and dissected open to remove gastrointestinal tract. Ileum and colon pieces (10 cm long) are assessed for inflammation on macroscopic score and histopathological studies. Pretreatment with MEO has shown a decreased in macroscopic scores for inflammation as compared to indomethacin treated group. A significant decrease in serum lactate dehydrogenase level was also observed in MEO treated groups. Histopathology examination of MEO treated group revealed less damage compared to indomethacin treated group. The finding of present study provides evidence that Emblica officinalis may be beneficial in patients with inflammatory bowel diseases. {\textcopyright} 2010 Academic Journals Inc.