Human and Organizational Factors (HOFs) play an important role in the safe, reliable, and maintainable operation of the CNC turning center (CNCTC). Several human performance influencing factors (PIFs) and organizational factors (OFs) influence the human reliability. In this paper, some human PIFs and OFs which may affect the human reliability during maintenance phase are defined and considered for the prioritization according to their criticality using the expert judgments. It is observed that experience is the most important human performance influencing factor (PIF) and safety culture is the most critical organizational factor (OF) affecting the human reliability. The time-between-failure (TBF) and time-to-repair (TTR) data significantly influenced by HOFs are analyzed using the techniques of reliability and maintainability, and the results of the analysis are compared with those of the TBF and TTR data which are not significantly affected by HOFs. The field failure and repair data were sorted considering the influence of hardware, software, and HOFs using expert judgments and outcomes of reliability and maintainability analysis. It has been observed that 16.33% of the total failures and 15.49% of total repairs are significantly influenced by HOFs. Nearly 66% of the total failures and repairs are due to hardware system. The reliability and maintainability of the CNCTC are greatly influenced by HOFs. The HOFs can reduce the expected life of the components or sub-systems of the CNCTC by 33%. © 2020, Springer Nature Singapore Pte Ltd.