Kukkutandatvakbhasma (Hen Egg shell bhasma) which is known as calcinated Hen egg shell is used in the treatment of leucorrhea in the form of bhasma since ancient times in Ayurveda system of medicines.It is known to have anti-inflammatory, anti-arthritic, rejuvenative for heart and aphrodisiac property.Hence, the objective of present study was to explore its anti-inflammatory activity of Kukkutandatvakbhasma through appropriate animal models.The Kukkutandatvakbhasma of both types of hen egg shell i.e. modern (KKBM-7)and gavran (KKBG-7) was prepared separately using Putapaka method in three steps – Shodhan (purification), Marana and Bhavana. Anti-inflammatory activity of KKBM-7 and KKBG-7 was evaluated using carrageenan inducedpaw edema and Adjuvant-induced chronic arthritis models.Treatment with KKBM-7 (300 and 500 mg/kg) and KKBG-7 (300 and 500 mg/kg) reducedcarrageenan induced rat paw edema volume. Treatment with KKBM-7 (300 and 500 mg/kg) and KKBG-7 (300 and 500 mg/kg) significantly reduced paw volume compared to control group from day 3 till day 21 in Adjuvant-induced chronic arthritismodel.thus, it was concluded that KKBM-7 and KKBG-7 have significant anti-inflammatory activity in acute as well as chronic model of inflammation. © 2018, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.