Problems associated with asphaltene deposition are key challenges for the upstream industry. In this research work, systematic experimental studies of asphaltene precipitation were conducted for two different Iranian crude reservoirs. Though gas injection in the reservoir enhances the crude productivity, it leads to higher precipitation of asphaltene compared to the natural depletion conditions. State of the art software tool namely CMG was utilized to predict the performance of the reservoirs for natural depletion condition as well as at high gas injection conditions. The CMG based predictions matched well with the experimental observations for both the reservoirs with reasonable accuracy. © 2019 Petroleum and Coal.