Era has arisen to circumvent the application of conventional oral dosage forms and explore these novel drug delivery approaches to gain better benefits. Present investigation was carried out in the view to develop and characterize the mucoadhesive polymeric microparticles of mucilage obtained from natural resource i.e. Linum usitatissimum in order to prolong the release and overcome the drawbacks such as shorter half life and gastrointestinal irritation of dexibuprofen. L. usitatissimum mucilage was isolated and combined with sodium alginate for its fabrication into microparticles. Various batches were formulated and characterized, the results of FITR and DSC studies revealed the compatibility between drug and polymers. Apart from this, percent mucoadhesion was found to be in the range of 50-85%, whereas particle size was found in the range of 830-865 $\mu$m. Optimized formulation was successful in releasing the drug for the prolonged time period of 12 h. Overall study indicated that natural mucilage can be efficiently utilized to retard the drug release and minimize the side effects of the drug, so as to get maximum utilization of the therapeutic dose.