Good nutrition plays a vital role in the overall growth, health, and immunity of human beings. Optimum immune function protects the body from pathogenic infections and malignancy (cancer). Because of traditional literature documentations, medicinal plants such as fenugreek are gaining interest as good nutrition and immune enhancement sources. Fenugreek is documented as an immunomodulatory and growth-promoting dietary spice in traditional literature. Furthermore, the immune enhancement potential and use in management for infection, immunology, and cancer have been recorded in many reported modern scientific studies. The present chapter reviews the existing body of evidence involving the exploration of fenugreek for the optimum growth, immunity enhancement, and management of immunological (allergic, autoimmune) infectious and malignant (cancer) disorders with their suggested mechanism of actions. © 2022 selection and editorial matter, Dilip Ghosh and Prasad Thakurdesai, individual chapters, the contributors.