In recent times, nanotechnology has emerged as one of the key driving factors in the technological and scientific advancements around the globe. The material property enhancement is the key towards various applications of nanotechnology. The incorporation of nanoparticles into a matrix of standard material can enhance specific mechanical and thermal properties. Graphene oxide is one such compound with excellent dispersibility that is widely used to enhance the mechanical properties of certain ceramics and polymers. The main objective of this study was to determine the variation in the flexural properties of S-2 glass/epoxy nanocomposite laminates with different concentrations ranging from 2% to 8% of graphene oxide (w/w %) using finite element analysis (FEA). The test specimen matrix layup was selected as 0/45/-45/90/90/-45/45/0 (8 layers). The test setup for FEA and specimen dimensions were selected according to the ASTM D790 test standard for three-point bending test. It was observed that the incorporation of graphene oxide into S-2 glass/epoxy matrix enhances the flexural strength up to 6% of graphene oxide concentration. The flexural strengths of 2%, 4% and 6% graphene oxide laminates were increased by up to 10%, 57% and 80% respectively with respect to pure S-2 glass/epoxy laminate. This enhancement in the flexural strength can prove to be extremely beneficial for aerospace and structural applications. © 2021 Elsevier Ltd. All rights reserved.