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Formulation and evaluation of aceclofenac sustained release tablets
Srinivas Kumar Ashok,
Published in Global Research Online
2014
Volume: 28
   
Issue: 2
Pages: 59 - 63
Abstract
Increase in complication and expenses involved in marketing of new drug entities has focused greater attention in development of sustained release drug delivery system of existing drugs. NSAID are having short biological half life of 4-4.3 hrs and fluctuation in drug plasma concentration. NSAID are used in symptomatic treatment of rheumatoid arthritis & spondylitis. They have analgesic, anti inflammatory, antipyretics activity. Aceclofenac sustained released tablets was developed using wax and polymer matrix in the different ratio. The evaluation of granules was carried for angle of repose, Hausner's ratio, Carr's compressibility index. Tablets were evaluated for hardness, uniformity of weight, content of active ingredient, thickness, in-vitro dissolution studies. The results of hardness showed that as the concentration of wax or polymer increases, the hardness of tablet increases. The in-vitro dissolution study showed that for the formulation containing Aceclofenac with highest concentration of wax and polymer showed maximum sustained activity. Formulation containing bees wax and Carnauba wax in ratio 1:0.5 were optimized based on in-vitro dissolution and hardness. The dispersion of the drug in the wax and polymer network altered its dissolution profile at pH 6.8, thus making it possible to obtain a gradual and prolonged release and to modulate the release pattern.
About the journal
JournalInternational Journal of Pharmaceutical Sciences Review and Research
PublisherGlobal Research Online
ISSN0976044X
Open AccessNo