The immunomodulatory activity of an Indian medicinal plant i.e. ethanolic extract from Dodonaea viscosa L.F. namely DV was studied for there phagocytic activity, cell mediated and humoral immune system on rat/mouse. Immunomodulatory effect was assessed in carbon clearance test, delayed type of hypersensitivity (DTH), T-cell population test and sheep erythrocyte agglutination test (SEAT) in animal treated with DV at doses of 200 and 400 mg/kg. In carbon clearance test, D.viscosa exhibited significantly high phagocytic index against control group, indicating stimulation of the reticulo-endothelial system. Significant decrease in mean difference, in the foot paw thickness in DTH indicates its anti-inflammatory activity. In SEAT D. viscosa treated groups at 200, 400 mg/kg doses in normal immune status animals while In T-cell population test, showed significant increase in T-cell rosette formation against control. These results confirm the immunomodulatory activity of D. viscosa extract, which is a known immunomodulator in indigenous medicine.