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Improvement of dissolution rate of Ramipril by solid dispersion technique and devlopement of buccal patch
Published in
Volume: 4
Issue: SUPPL. 5
Pages: 309 - 318
Ramipril is an ACE inhibitor mainly used for management of mild to severe hypertension and myocardial infarction. The poor solubility and wettability of Ramipril leads to poor dissolution and hence showing variations in bioavailability. The present study is aimed to increase solubility and dissolution of the drug using solid dispersion techniques. The formulations were characterized by solubility studies, X-Ray Diffractometry studies, differential scanning calorimetry, Fourier transform infrared spectroscopy and in vitro dissolution rate studies. The solubility of drug increased linearly with increase in polymer concentration showing AL type solubility diagrams. The solid dispersions of the drug demonstrated higher drug dissolution rates than physical mixtures and pure Ramipril. The kneaded complex method showed higher dissolution rate than other complex method and it was incorporated into buccal Patches. The patches were prepared by solvent casting method using HPMC K15 and Poloxomer WSR205NF. The patches were found to be smooth in appearance, uniform in thickness, weight uniformity, drug content, swelling index, folding endurance, surface pH and in vitro diffusion study using Keshery chien diffusion cell. The Patch of 0.5% HPMC K15 exhibit in vitro release of 78.16% through cellophane membrane and 72.16% release through egg membrane and the patch of 0.5% Poloxomer WSR205 NF exhibit in vitro release of 74.24% through cellophane membrane and 69.44% release through egg membrane in 8 hrs showing good mucoadhesive strength and mucoadhesive time. The optimised patch was subjected to ex vivo studies through goat buccal mucosa showed 60.47% release in 8 hrs.
About the journal
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Open AccessNo