New era is an era of Novel Drug Delivery system. Formulation research is oriented towards increasing safety and efficacy of existing drug molecule through novel concepts of drug delivery. Salbutamol sulphate is a selective $\beta$2 receptor agonist widely used as bronchodilator. It forms part of initial therapy of acute as well as chronic asthma. In present work an attempt has been made to formulate and evaluate mouth dissolving tablets of salbutamol sulphate. Formulations were designed by factorial design technique. Sodium starch glycolate, crosscarmellose sodium and treated agar were used as super-disintegrants while microcrystalline cellulose was used as diluent. Direct compression technique was used as it requires conventional tablet machinery and thus economical process. Formulations containing sodium starch glycolate alongwith other super-disintegrants, showed rapid in-vitro and in-vivo dispersion time, as compared to other formulations.