The upsurging human population subsequently elevate the demand for food thereby creating immense strain on the agriculture sector worldwide. Varied types of biotic and abiotic factors are responsible for impairing the plant’s health, therefore efficacious management strategies for these factors are required for food security. The diverse conventional methods for controlling plant diseases come up with numerous unavoidable limitations. The development of novel competent strategies which can provide the solutions for plant disease management needs more attention. Herein, we expanses the knowledge about the new field that is nanophytovirology to specifically combat plant viral diseases. Nanophytovirology is the budding area attracting more attention day by day because the area can control plant viral diseases with efficient well-versed methods that involve the use of nano-sized materials. Nanomaterials can be used as antivirals, as delivery systems, as biostimulants and also as sensitive and selective detection systems for phytoviral infections. Mainly various metallic and metal oxides nanoparticles were explored for their antiviral activity, although nanomaterial delivery systems for combating viral diseases need to be considered more. However, the potentials of nanomaterials as delivery systems are very well highlighted in the chapter. Further, nanomaterials have a great ability to enhance plant immunity by their biostimulation phenomenon. The nanomaterials are ideal agents to effectively diagnose and detect plant viral diseases with the help of functional, portable, rapid, sensitive and selective nanobiosensors. © 2023 Sunil K. Deshmukh, Mandira Kochar, Pawan Kaur and Pushplata Prasad Singh.