Over the decades the outcome of industrial compliance, manufacturing process, formulation and development, Hot Melt Extrusion (HME) also expanded the acceptance. As a result of industrial adaptability, it has developed itself into a wide range pharmaceutical research development. New drug entities face failures or delays during formulation development, including poor biopharmaceutical properties toxicity, lack of efficacy, or both. To overcome such obstacles, the HME technique is preferred one. In comparison to conventional techniques, its use is increasing because of its process, solvent free nature, cost effective, and on-line manufacturing. For achieving different applications, several dosage forms can be produced by altering the design of equipment and adapting a modified processing condition. © 2022, Hacettepe University, Faculty of Pharmacy. All rights reserved.