Resting-state fMRI (rsfMRI) was firstly characterized by Biswal et al [1] in the year 1995 and since then it is used for studying patients with various neurosurgical, neurologic, and other brain-related disorders. Various statistical methods are used to analyze the resting-state functional magnetic resonance imaging connectivity. This paper attempts to explore more on the learning of resting-state functional magnetic resonance imaging connectivity. This study will help to understand the usage of rsfMRI to evaluate functional connectivity in the human brain and its usage for surgical decision-making for drug-resistant epilepsy. This paper explains the significance of such connectivity analysis, the methods available for it, and the shortcomings associated with the data.