A simple, rapid and precise reversed-phase liquid chromatographic method is developed for simultaneous determination of Aliskiren and Hydrochlorothiazide in their binary mixture of commercial pharmaceutical preparations. This method, reported first time for a binary mixture, uses a Kromasil C18, 250 × 4.6 mm, 5 $\mu$m analytical column. Analytes were estimated by isocratic elution with acetonitrile (ACN): tetrahydrofuran (THF):water (71: 13: 16% v/v) mobile phase (pH adjusted to 3 with ortho phosperic acid) at flow rate of 0.5 mL/min; the column maintained at 50°C and detector was set at 229 nm. The sample concentrations are measured on weight basis to avoid the internal standard. The method is validated and shown to be linear. The correlation coefficients for aliskiren and hydrochlorothiazide are 0.9998 and 0.9994, respectively. The recovery values for aliskiren and hydrochlorothiazide ranged from 99.25-99.54% and 98.84-100.01%, respectively. The relative standard deviation for six replicates is always less than 2%. The method is successfully applied for simultaneous quantitative analysis of the title drugs in combined tablets.