A simple, accurate, rapid and sensitive method has been developed for the estimation of melatonin and meloxicam using Folin-Clocalteu reagent in the presence of 20% sodium carbonate solution. The blue coloured chromogen formed Is measured at wavelength of maximum absorption 700 nm against reagent blank. The chromogen obeyed linearity over 1.5 to 15 $\mu$g/ml for melatonin and 1.5 to 22.5 $\mu$g/ml for meloxicam.