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Spectrophotometric methods for the estimation of ethamsylate in tablets
, V. Randive S., A. Chaudhari P., S. Bhise B.
Published in
2003
Volume: 65
   
Issue: 2
Pages: 184 - 188
Abstract
Two simple, accurate, rapid and sensitive methods have been developed for the estimation of ethamsylate in pharmaceutical dosage forms. Method A is based on the reduction of Folin-Ciocalteau phenol reagent by ethamsylate in presence of 20% sodium carbonate solution giving blue chromogen, which shows maximum absorption at 740 nm while method B is based on the reduction of ferric ions (ferric nitrate) to ferrous ions by ethamsylate which then reacts with 1,10-phenanthroline to produce reddish coloured complex showing maximum absorption at 435 nm against reagent blank. In both the methods Beer's law was obeyed in the concentration range of 5-25 $\mu$g/ml.
About the journal
JournalIndian Journal of Pharmaceutical Sciences
ISSN0250474X
Open AccessNo