A simple, rapid, economical, precise and accurate method for simultaneous determination of Aspirin (ASP) and Ticlopidine (TIC) in combined dosage form has been developed. The first method was First Order Derivative Spectroscopy (Method A) in which derivative amplitudes were measured at selected wavelengths. Second method was Area Under Curve (Method B) and third method was Ratio Derivative spectroscopy (Method C). Methanol was used as solvent for all the three methods. The amplitudes at 232.98 nm and 239.50 nm in the first order derivative spectra were selected to determine ASP and TIC, respectively. The wavelength ranges 234.15-238.88 nm and 215.30-219.50 nm were selected to determine ASP and TIC by AUC method. Amplitude at 224.61nm and 234.50 nm were selected in the ratio derivative spectra to determine ASP and TIC, respectively. Beer's law was obeyed in the concentration ranges of 2-10μg mL-1 and 5-25 μg mL-1 ASP and TIC, respectively in all three methods. The % assay for commercial formulation was found to be in the range 99.12% - 101.21 % for ASP and 98.92 - 100.20 % for TIC by the proposed methods. Recovery was found in the range of 98.74 - 101.24 % for ASP and TIC in the Formulations. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods which were carried out by following ICH guidelines.