A simple, precise and accurate methods for simultaneous determination of Cefixime (CEF) and Ofloxacin (OFL) in combined tablet dosage form has been developed. The method is based on Ratio spectra derivative and Area under curve (AUC) spectrophotometry using methanol and 0.1 N HCl, respectively as solvents. The amplitudes at 319.11 nm and 347.40 nm in the first derivative of the ratio spectra were selected to determine CEF and OFL, respectively and wavelength ranges of 277-279 nm and 296-298 nm were selected to determine CEF and OFL by AUC method in combined formulation. Beer's law is obeyed in the concentration range of 5-25 μg/mL and 4-20 μg/mL by Ratio spectra derivative and Area under curve method, respectively for both the analytes. The % assay in commercial formulation was found to be in the range 99.01 - 100.90 % for CEF and 98.91 - 101.72 % for OFL by the proposed methods. The methods were validated with respect to linearity, precision and accuracy. Recovery was found in the range of 98.60 - 101.80 % for CEF and 98.75 - 100.2% for OFL by ratio derivative method and 98.16 - 100.4% for CEF and 98.89-100.21% for OFL by AUC method respectively for both the Formulations. The methods developed are simple, economical, precise and accurate and can be used for routine quality control of combined tablets. AUC method was successfully applied to carry out dissolution study of commercial tablet formulation by using USP II dissolution test apparatus.