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Spectrophotometric simultaneous Determination of Clopidogrel and aspirin in combined tablet dosage form by ratio derivative and area under curve method

Published in
Volume: 4
Issue: 1
A simple, economical, precise and accurate method for simultaneous determination of Clopidogrel (CLOP) and Aspirin (ASP) in combined tablet dosage form has been developed. The first method is based on Ratio Spectra Derivative (Method A) and second method is based on Area under Curve (AUC) Spectrophotometry (Method B). The amplitudes 218.11 nm and 247.002 nm in the second derivative of the ratio spectra were selected for aspirin and clopidogrel respectively. In the second method (AUC) areas were integrated in the wavelength ranges between 215.66-218.78 nm and 235.15-238.27 with reference to the absorbance curves plotted between the wavelengths 200-350 nm to determine CLOP and ASP. The drugs obey Beer's law in the concentration range of 5-25 μg mL -1 by both the methods. The methods were validated with respect to linearity, precision and accuracy. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods which were carried out by following ICH guidelines. The proposed methods were applied successfully for Simultaneous Determination of Clopidogrel and Aspirin in Combined Tablet formulations. © RJPT All right reserved.
About the journal
JournalResearch Journal of Pharmacy and Technology
Open AccessNo
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