Present work describes the synthesis of (2E)-1-(8-hydroxyquinolin-7-yl)-3-(Aryl) prop-2-en-1-one, derivatives of Chalcones. Starting material 8- hydroxy quinoline was acetylated and subjected to fries rearrangement reaction to yield 7- acetaldehyde-8-hydroxy quinoline which on aldol condensation with various derivatives of benzaldehyde yields 13 compounds. The compounds have been characterized and evaluated for anti-bacterial activity. MIC values of the compounds showing higher zone of inhibition was found to be 100 $\mu$g/ml. The activity of the compounds can be attributed to the substitution of electronegative groups in the synthesized compounds. {\textcopyright} RJPT All right reserved.