The purpose of this paper is to investigate stress distribution pattern around implant-bone interface of commercially available different thread profile dental implants using finite element analysis and experimental verification by photo elastic stress analysis. A two-dimensional Finite Element Model of implant prosthesis (Implant, abutment, screw, & human bone) is modeled using commercial software code. Occlusal load on teeth is applied as static load on the abutment to find the shear stress around implant-bone interface. Photo elastic model is prepared using acrylic material, having homogenous mixture of Araldite Resin CY 230 and hardener HY 951. Screwing and drilling of implant in the photo elastic model is done by dentist in the lab. Tardy’s method is used for noting the fringe order at a particular point to predict the stress intensity in the acrylic model. Scaling method is used to predict the shear stress in the cancellous bone from the measured stress intensity of photo elastic model. The current research work reveals stress distribution pattern with different implant systems. The highest value of stress is observed in the model fitted with reverse buttress thread profile at apical portion of implant while least value was observed for implant fitted with V thread profile at critical section, and is found to be the best profile amongst the other two from maximum shear stress criteria.