Several finite element models of bone-implant prosthetic derived with geometrical topology and material properties. Most of them adopted linear isotropic material properties to predict stresses around bone-implant interface. The objective of the present study is to compare stress distribution around bone-implant interface between two material models. In order to understand the biomechanical stress behavior at bone-implant interface, four different implant models were selected for the study. Mandibular bone section material models for isotropic and orthotropic material is defined with the contact between bone and implant surface to predict the von Mises stresses in the cancellous and cortical bone under the influence of vertical load of 100 N (coronal-apical), lateral load of 40 N (mesial-distal), and oblique load of 100 N at 45° to the axis of implant on crown surface. A nonlinear Abaqus CAE code is used to predict stresses distribution comparison between two material models.The current study compares the result of stress in cancellous and cortical bone with isotropic and orthotropic material models. The stress distribution along the interface was presented for vertical, lateral, and oblique loading of selected implant models. Finite element (FE) numerical simulation result shows that the orthotropic material model is more acceptable than the isotropic material model to predict stress along bone-implant interface.