MIT-World Peace University (MIT-WPU) is a top educational institute located in Pune, India. It is recognized within&nbsp;UGC under Government of Maharashtra Act No. XXXV 2017.&nbsp;

It is part of the MIT group of institutions (established in 1983) which covers 10+ campuses across India and has more than 50,000+ students enrolled across various disciplines at a given point of time. The institute houses 15 schools ranging from Engineering &amp; Technology, Design, Pharmacy, Commerce, Governance among others. It offers undergraduate, postgraduate and PhD programs among different disciplines.&nbsp;

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MIT World Peace University

The present study deals with studies on Cilostazol &amp; $\beta$-cyclodextrin($\beta$CD) inclusion complexs. . The present research work describes formation of Cilostazol &amp; $\beta$-cyclodextrin complexes. using Kneading, Coevaporation &amp; physical mixture with molar proportion of $\beta$-CD (1:1). Cilostazol,6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-3,4-dihydro- 2(1H)-quinolinone.is a vasorelaxent drug &amp; act as a platelet aggregation inhibitor. Cilostazol exhibits low aqueous solubility, which accounts variability in oral bioavailability. Hence, the main objective of study was to investigate the possibility of improving the solubility &amp; dissolution rate of Cilostazol via complexation with $\beta$-CD. Phase solubility studies revealed the existence of 1:1 complex between cilostazol and $\beta$-CD.Prepared inclusion complexes were characterized by I.R, UV. In vitro release of Cilostazol from inclusion complexes were studied by dissolution study in 0.1N HCl, pH 6.8 and distilled water. It was observed that complexes exhibit higher dissolution rates than the pure drug.

World University root node

School of Pharmacy

Pharmacy

International Journal of PharmTech Research

Studies on cilostazol and β-cyclodextrin inclusion complexes

The reaction of substituted salicyaldehydes with hydrazine hydrochloride under different conditions gave the corresponding 1-H indazoles. However, the reaction of benzaldehydes with hydrazine hydrate under the same conditions yielded only hydrazones. © 2007 Elsevier Ltd. All rights reserved.

Tetrahedron letters

An efficient synthesis of 1-H indazoles

Roots of the plant Inula racemosa are used as folk medicine in east Asia and Europe. Inula racemosa in combination with Commiphora mukul was reported to cure myocardial ischemia. However, systematic investigation of the plant for its specific role in heart diseases has not been conducted so far. In the present study, we have reported the isolation of four major constituents A, B, C and D along with some minor constituents from the plant Inula racemosa. Among the major constituent, constituent Dhas been selected first from spectral data and studied for its cardiac activity on isolated frog heart. The experimental data show that constituent D decreases heart rate and force of contraction at 40 mcg/ml. Actions of Adrenaline are blocked by constituent D and it also acts as an agonist for Propranolol. The studies indicate that constituent D produces a negative ionotropic and negative chronotropic effect on frog's heart. These studies can be utilized as a cardiac marker for exploring the cardiac activity of the plant Inula racemosa. Copyright {\textcopyright} by The Haworth Press, Inc. All rights reserved.