MIT-World Peace University (MIT-WPU) is a top educational institute located in Pune, India. It is recognized within&nbsp;UGC under Government of Maharashtra Act No. XXXV 2017.&nbsp;

It is part of the MIT group of institutions (established in 1983) which covers 10+ campuses across India and has more than 50,000+ students enrolled across various disciplines at a given point of time. The institute houses 15 schools ranging from Engineering &amp; Technology, Design, Pharmacy, Commerce, Governance among others. It offers undergraduate, postgraduate and PhD programs among different disciplines.&nbsp;

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MIT World Peace University

Background: Analysis of tertiary mixtures of analytes along with their impurities with simple and cost effective manner is always of interest. Utility of chemometric techniques are growing in pharmaceuticals, it improve speediness in the analysis and also provide analytical solutions with reduce the number of steps in the analytical method. In this study UV-Visible spectrophotometry coupled with principle component regression (PCR) and partial least square (PLS) multivariate methods was applied for estimation of three drugs in their formulation. Method: The calibration and validation sets were prepared in linear concentration range of three drugs and major impurities of paracetamol and aceclofenac. The series of sets were prepared using multilevel multifactorial design. Leave-One-Out (LOO) cross validation technique was employed to get essential number of Latent variables (LVs) that provides the greatest predictive ability. The developed method was studied for qualitative and quantitative analysis of titled drugs and validated as per regulatory guidelines. Results: The results showed the values of coefficient of determination (R2) for all drugs and impurities was higher than 0.99 indicating high acceptability. The obtained RMSE values were relatively low. Coefficient of determination and RMSE values indicate good accuracy and precision, respectively. Conclusion: Proposed method was successfully used for analysis of aceclofenac, paracetamol and chlorzoxazone in tablet dosage form and major impurities of aceclofenac, paracetamol in bulk. © 2022 American Society of Civil Engineers (ASCE). All rights reserved.

World University root node

School of Pharmacy

Pharmacy

School of Petroleum Engineering

Engineering and Technology

Biomedical and Biotechnology Research Journal

Development and validation of chemometric-assisted spectrophotometric method for the simultaneous estimation of aceclofenac, paracetamol, and chlorzoxazone with impurities

We investigate methodologies for improving the results of Physics Informed Neural Networks-Neural Networks that are trained with the supervision of relevant physical laws to solve specific problems. The methods we look into in this work are implementing the ResNet architecture and implementing Fourier Feature Mapping to allow the network to learn high-frequency features. We implement these methods to train a PINN on the 1D Burger's Equation. The predictions of the PINNs are compared against the solution from a Finite Difference Method based solver along with a baseline performance of a simple densely connected network. © 2022 IEEE.

School of Electronics & Communication Engineering

2022 6th International Conference on Computing, Communication, Control and Automation, ICCUBEA 2022

Physics Informed Neural Networks-A Methodology Review

Two simple, economical, precise and accurate methods for simultaneous determination of Drotaverine (DRT) and Nimesulide (NIM) in combined dosage form have been developed. The first method is Ratio Derivative spectroscopy method (Method A) in which ratio derivative amplitudes were measured at selected wavelengths. Second method is Dual wavelength Spectrophotometry (Method B). The amplitudes at 344.8 nm and 243.5 nm in the Ratio derivative spectra were selected to determine DRT and NIM, respectively and wavelengths 254.008, 274.68 nm and 221.09, 232.067 nm were selected to determine DRT and NIM, respectively by dual wavelength method in methanol. Beer's law is obeyed in the concentration ranges of 8-24 $\mu$g mL -1 and 20-60 $\mu$g mL -1 for DRT and NIM, respectively in methanol for both the methods. The % assay for commercial formulation was found to be in the range 99.91-100.91% for DRT and 99.84 - 101.07% for NIM by the proposed methods. Recovery was found in the range 99.18-100.10 for DRT and 99.52 - 101.09% for NIM by ratio derivative spectroscopic method and 99.82 - 101.12% for DRT and 99.73-101.09% for NIM by dual wavelength method for both the Formulations. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and of the proposed methods which were carried out by following ICH guidelines.

Der Pharma Chemica

Determination of drotaverine and nimesulide in combined tablet dosage form by ratio derivative spectroscopy and dual wavelength spectrophotometric methods

Three simple, economical, precise and accurate UV Spectrophotometric methods have been developed for the estimation of Mycophenolate sodium in bulk and pharmaceutical formulations. Method A involves measurement of absorbance of solution at 250.23 nm in methanol. Method B involves measurement of integrated area under curve in the wavelength range of 248.07 nm - 250.03 nm and is used to construct calibration curve. Method C is first order derivative spectroscopy method, in which first order derivative amplitude at 258.42 nm is measured. Linearity for detector response was observed in the concentration range of 10 - 50 $\mu$g/ml for all the three methods in methanol. The results of analysis have been validated as per ICH analytical method validation guidelines. Accuracy, precision and recovery studies were carried which confirmed the validity of the proposed methods. {\textcopyright} RJPT All right reserved.

Research Journal of Pharmacy and Technology

Development and Validation of UV Spectrophotometric Methods for Estimation of Mycophenolate Sodium in Bulk and Pharmaceutical Formulations

A simple, economical, precise and accurate method for simultaneous determination of Clopidogrel (CLOP) and Aspirin (ASP) in combined tablet dosage form has been developed. The first method is based on Ratio Spectra Derivative (Method A) and second method is based on Area under Curve (AUC) Spectrophotometry (Method B). The amplitudes 218.11 nm and 247.002 nm in the second derivative of the ratio spectra were selected for aspirin and clopidogrel respectively. In the second method (AUC) areas were integrated in the wavelength ranges between 215.66-218.78 nm and 235.15-238.27 with reference to the absorbance curves plotted between the wavelengths 200-350 nm to determine CLOP and ASP. The drugs obey Beer's law in the concentration range of 5-25 μg mL -1 by both the methods. The methods were validated with respect to linearity, precision and accuracy. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods which were carried out by following ICH guidelines. The proposed methods were applied successfully for Simultaneous Determination of Clopidogrel and Aspirin in Combined Tablet formulations. © RJPT All right reserved.

Spectrophotometric simultaneous Determination of Clopidogrel and aspirin in combined tablet dosage form by ratio derivative and area under curve method

A simple, precise, rapid and accurate RP-HPLC-PDA method has been developed for the simultaneous estimation of drotaverine HCl (DRT) and aceclofenac (ACE) in combined tablet dosage form. Formulation containing DRT with ACE are used as antispasmodic and anti-inflammatory agent. The chromatographic separation was achieved on Qualisil BDS C8 column (250 mm × 4.6 mm, 5.0 $\mu$ particle size) using methanol: THF: acetate buffer (68:12:20 v/v) pH adjusted to 5.0 with acetic acid, flow rate was 1.0 mL min-1 and column was maintained at 50°C. Quantification and linearity was achieved at 298 nm over the concentration range of 1 - 150 $\mu$g mL-1 for Drotaverine HCl and 1.25 - 187.5 $\mu$g mL-1 for Aceclofenac. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness. The proposed method was optimized and validated as per the ICH guidelines. {\textcopyright} Pharmascope Foundation.